Formulation Development and Evaluation of Oro-Dispersible Tablets Based On Solid Dispersion of Cimetidine

The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach which oral dispersible tablet. Oral tablet also called as mouth dissolving tablet, fast or disintegrating has advantage it quickly disintegrates into saliva when put on the tongue. faster drug dissolved, absorption and quicker therapeutic effect of will be attained. objective present study was to formulate directly compressible orodispersible tablets cimetidine with improved solubility bioavailability by using solid dispersion technique. Cimetidine histamine H2-receptor antagonist. It widely prescribed active duodenal ulcers, gastric Zollinger-Ellison syndrome, gastroesophageal reflux disease erosive esophagitis. Solid prepared anti-solvent addition method physical mixture novel polymer eudragit E 100. Saturation determined formulation. formulations were further characterized contents, HPLC, encapsulation efficiency. Orodispersible direct compression blend evaluated for pre-compression parameters such bulk density, compressibility, angle repose etc. selected formulation excipients sodium starch glycolate superdisintegrant hardness, friability, weight variation, content uniformity, wetting time, time in-vitro release. shows 27±1 seconds release 93.20±3.181%, better compare containing pure (82.36±1.986) within 20min. Thus showed increased patient complies convenience.
 Keywords: Cimetidine, tablets, dispersion, Anti solvent method, Superdisintegrant